Giant cell arteritis is the most common form of vasculitis in adults. Early diagnosis and treatment plays a crucial role in preventing severe complications or even relapse. Therefore, in this project promising serological markers for diagnostic and prognostic use were identified, with the goal of enabling personalized disease management to benefit the patients.
Eingereicht von: Julia Feichtinger, PhD
Firma/Universität: Graz University of Technology; Omics Center Graz
Kooperationspartner: University Medical Centre Ljubljana, Biomedis M.B. d.o.o.
The team highlights the importance of using groups of serological analytes in clinical applications. The benefit of GCA biomarker panels for the patients is clearly a simple, cost-efficient and minimally invasive method for early diagnosis as well as for monitoring and prognosis of the disease. Patients would undergo minimally invasive blood collection in comparison to highly invasive temporal artery biopsies, which are currently mainly used for diagnosis. Since methods to predict GCA complications, such as visual disturbances or even complete vision loss, are lacking to date, a personalized therapy and monitoring procedure could be set up for each individual patient, based on the test results. This in turn, will lead to improved prognosis for GCA patients and could prevent the manifestation of severe complications during the course of the disease.