An Ex Vivo 3 Dimensional Organotypic Culture Model: A First Attempt to Stimulate Endochondral Ossification of the Growth Plate in Vitro

Eingereicht von: Sriveena Srinivasaiah, MSc
Firma/Universität: Medical University of Graz – University Clinics for Orthopedics and Traumatology
Kooperationspartner: Helmholtz-Zentrum Geesthacht GmbH; Mayo clinic

  • - Foto: (c) Sriveena SrinivasaiahThe model can benefit the scientific and pharmaceutical community by providing an ultimate
    bone template that can be subjected to various testing’s.
  • This is a great model to investigate bone trauma and lesions caused in young children.
  • Most importantly from the ethical standpoint it reduces the use of animals and promotes
    alternative testing strategies.
  • Since it provides a scope to discover novel biomarkers, the knowledge could be substantially
    expanded to preclinical investigations and therapeutical interventions.
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