Graphene oxide-based nanocomposites for drug delivery in chemotherapy

Proper functionalization of GO with biocompatible polymers and traditional anticancer drugs is projected for antitumor and C hepatitis treatment with better therapeutic effects and reduced side effects associated to traditional anticancer drugs (campthothecin derivatives, doxorubicin, cisplatin).

Eingereicht von: Javier Pérez Quiñones, MSc
Firma/Universität: JKU University Linz – Institute of Polymer Chemistry
Homepage: www.jku.at
Kooperationspartner: JKU University Linz – Institute of Polymer Chemistry; University of Havana – Center of Biomaterials

life-science.eu - Foto: (c) Javier Pérez QuiñonesDoxorubicin is a traditional and widely employed anticancer drug with important side effects that include life threatening conditions such as cardiomyopathy with subsequent congestive heart failure, myelosuppresion and acute bowel infection [6,16]. On the other hand, camptothecin is a potent antitumor agent with also known activity against hepatitis C virus, but its high toxicity, low aqueous solubility and reduced stability at physiological conditions have precluded its clinical use [7,8]. Then, two camptothecin derivatives (Irinotecan and Topotecan) are aproved by FDA for anticancer treatments, but their therapeutic efficiency is one order or lower than the parent drug [4]. Therefore, it is necessary to develop novel formulations for delivery of doxorubicin and camptothecin with better therapeutic effects achieved with lower doses and reduced side effects during chemotherapy treatments. The projected GO-biopolymer-vitamins or -testosterone composites forming nanoparticles and scaffolds for tissue engineering with a controlled release of doxorubicin and camptothecin are promising candidates for antitumor treatments.

  1. Tacar O. et al. Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems. J. Pharm. Pharmacol. 2013, 65: 157−170.
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