Die therapeutische Effizienz vieler topisch applizierter Arzneimittel zur Behandlung der zystischen Fibrose wird durch eine Schleimbarriere stark eingeschränkt.  Die Entwicklung von selbstemulgierenden Wirkstoffabgabesystemen (self-emusifying drug delivery systems; SEDDS) ermöglicht jedoch diesen Schleim zu überwinden und somit entscheidend effizientere Arzneimittel gegen diese Erkrankung zu entwickeln.

Eingereicht von: Univ.-Prof. Dr. Mag. pharm. Andreas Bernkop-Schnürch
Firma/Universität: Universität Innsbruck
in Kooperation mit: Thiomatrix Forschungs- und Beratungs GmbH

The therapeutic efficacy of numerous topically administered drugs for treatment of cystic fibrosis (CF) is strongly limited by the mucus gel barrier covering the target tissues. In particular CFTR (cystic fibrosis transmembrane conductance regulator) gene replacement therapy and inhaled antibiotic therapies have by far not reached expectations mainly due to inefficient delivery systems. Drug carrier systems are, on the one hand, needed to provide sufficiently high cell uptake of gene constructs and to guarantee that antibiotics reach their target site on the mucosa and in the mucus. On the other hand, however, even nanocarrier systems are simply too big to move through the tight three-dimensional mucus network of cystic fibrosis patients. Within a large EU-project (http://www.alexander-fp7.eu/ ) the Institute of Pharmacy and ThioMatrix generated in collaboration various promising novel strategies enabling nanocarriers to move through viscous mucus. In particular, self-emusifying drug delivery systems (SEDDS) with zeta potential changing properties showed high potential. It is therefore the objective of this collaboration to develop highly efficient SEDDS for topical delivery of CFTR gene constructs and antibiotics based on the knowledge gained from this EU-project.

Wir danken den Kooperationspartnern und Sponsoren

Bmwfw-web 1 Janssen Cilag Pharma oegmbt logo 100px  Christian Doppler Forschungsgesellschaft prazak
 Medizinische Universität Innsbruck  med-uni-graz-web muw100px  Veterinärmedizinische Universität Wien Universität Innsbruck
 Universität f. Bodenkultur Wien  Johannes Kepler Universität Linz Universität Wien uni-graz-web1 1
 Technische Universität Graz TU-Logo 1  Montan Universität Leoben  Donau Universität Krems  imc-fh-krems
impuls  Austrian Competence Centre for Feed and Food Quality, Safety & Innovation  Next Generation Fluorescence Imaging GmbH FH-Oberösterreich Fh Campus Wien
             
 cryomodultech Gefriersubstitution HyCentA Research GmbH texible hill-international papierholz austria
               
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